Description
AOD 9604 (Advanced Obesity Drug)
AOD 9604 is a modified form of amino acids 176-191 of the C-terminus of human growth hormone (HGH). Originally developed by Metabolic Pharmaceuticals as an anti-obesity drug, AOD 9604 has been researched for its potential effects on fat metabolism and weight loss without the adverse effects associated with full-length HGH.
Chemical Makeup
AOD 9604 is a synthetic peptide fragment containing amino acids 176-191 of human growth hormone with an added tyrosine residue at the N-terminal. This modification enhances its fat-burning properties while eliminating effects on blood sugar and tissue growth.
Research and Clinical Studies
AOD 9604 and Weight Loss
Research studies have demonstrated that AOD 9604 may stimulate lipolysis (the breakdown of fat) and inhibit lipogenesis (the formation of fatty acids and other lipids). In preclinical studies, subjects treated with AOD 9604 showed significant reductions in body fat, particularly around the abdominal region. The peptide appears to work by mimicking the way natural growth hormone regulates fat metabolism but without the adverse effects on blood sugar or growth that are seen with unmodified growth hormone.
One clinical trial showed that AOD 9604 administration led to an average fat loss of 2.8 pounds over 12 weeks compared to placebo, with the most significant effects observed in individuals with higher baseline body fat percentages. The peptide demonstrated a favorable safety profile with minimal side effects reported.
AOD 9604 and Metabolic Enhancement
Studies suggest that AOD 9604 may enhance metabolic rate and increase the body’s ability to burn fat as fuel. Research indicates that the peptide may activate beta-3 adrenergic receptors on fat cells, triggering lipolytic activity. Additionally, AOD 9604 has been shown to preserve lean muscle mass during caloric restriction, making it valuable for body recomposition goals.
AOD 9604 and Cartilage Repair
Interestingly, research has also explored AOD 9604’s potential role in cartilage repair and regeneration. Studies have indicated that the peptide may stimulate cartilage-producing cells (chondrocytes) and support joint health, providing additional benefits beyond fat loss.
AOD 9604 is available for research and laboratory purposes only. Please review our Terms and Conditions before placing an order.
References:
1. Heffernan M, et al. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. Endocrinology. 2001;142(12):5182-5189.
2. Ng FM, et al. Growth hormone variant hGH-AOD stimulates lipolysis in obese rodents. International Journal of Obesity. 2000;24(Suppl 2):S128.
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