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Product Specifications

• Product Name: GHK-CU (Copper)

• Form: Lyophilized peptide powder

• Intended Use: Research and laboratory use only

• Storage: Store according to label instructions

• Packaging: Sterile, sealed vial

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GHK-Cu (Copper Peptide / Tripeptide-1)

GHK-Cu is a naturally occurring copper-binding peptide consisting of three amino acids (Gly-His-Lys) complexed with a copper ion. This peptide is found naturally in human plasma, saliva, and urine, with levels declining with age. GHK-Cu has been extensively researched for its remarkable skin regenerative and anti-aging properties.

Chemical Makeup

GHK-Cu is a tripeptide with the sequence Gly-His-Lys (glycine-histidine-lysine) chelated with copper (Cu2+). The copper ion is essential for the peptide’s biological activity, as it facilitates various enzymatic reactions and cellular processes involved in tissue repair and regeneration.

Research and Clinical Studies

GHK-Cu and Skin Rejuvenation

Extensive research has demonstrated GHK-Cu’s powerful effects on skin appearance and health. Clinical studies show that topical application of GHK-Cu can increase skin thickness by 20-25%, improve elasticity by 18-22%, and reduce fine lines and wrinkles by 30-40% over 12 weeks of use. One landmark study demonstrated that GHK-Cu treatment resulted in a 70% increase in collagen type I production and a 160% increase in collagen type III production in cultured human skin fibroblasts.

Research indicates that GHK-Cu works through multiple mechanisms: stimulating collagen and glycosaminoglycan synthesis, promoting wound healing, activating tissue remodeling enzymes, and providing antioxidant protection. The peptide appears to reset the pattern of gene expression in aged skin to a more youthful state.

GHK-Cu and Collagen Production

Studies show that GHK-Cu is one of the most potent natural stimulators of collagen and elastin production. Research has demonstrated that the peptide increases mRNA expression for collagen types I, II, and III, as well as increasing decorin, a proteoglycan that regulates collagen synthesis. In vitro studies have shown 50-100% increases in collagen synthesis depending on concentration and cell type.

Clinical trials have observed significant improvements in skin density and firmness with GHK-Cu treatment. One 12-week study showed an average increase in skin density of 21% and improvements in skin laxity of 18% compared to placebo.

GHK-Cu and Skin Repair

Research indicates that GHK-Cu accelerates wound healing and tissue repair. Studies have shown that the peptide promotes angiogenesis (formation of new blood vessels), supports keratinocyte migration, and enhances fibroblast proliferation. In wound healing models, GHK-Cu treatment resulted in 30-40% faster wound closure and improved scar quality.

The peptide appears to modulate inflammatory responses while promoting constructive remodeling, leading to better healing outcomes with less scarring. Research shows reduced expression of inflammatory markers (TNF-α, IL-1, IL-6) by 40-60% in GHK-Cu treated tissues.

GHK-Cu and Anti-Aging Effects

Studies suggest that GHK-Cu may have systemic anti-aging effects beyond skin. Research has shown that the peptide can influence expression of over 4,000 genes, many involved in cellular housekeeping, DNA repair, and antioxidant systems. The peptide appears to suppress expression of genes associated with inflammation, tissue destruction, and cancer proliferation while upregulating genes involved in tissue repair and antioxidant defenses.

Clinical observations have shown improvements in skin texture, tone, and radiance with GHK-Cu treatment. Studies report 35-45% improvements in overall skin appearance scores, with effects on hyperpigmentation, sun damage, and age spots.

GHK-Cu is available for research and laboratory purposes only. Please review our Terms and Conditions before placing an order.

References:

1. Pickart L, et al. GHK and DNA: Resetting the Human Genome to Health. Biomed Res Int. 2014;2014:151479.
2. Leyden J, et al. Skin care benefits of copper peptide containing eye creams. Am Acad Dermatol. 2002.